Targeted Drug Screening & Profiling

Horizon Discovery

Horizon Discovery’s offering is based upon the creation and supply of a range of human cell-lines that represent patient-relevant isogenic somatic models of human genetic diseases.

Using a proprietary gene-targeting technology GENESIS, any genetic sequence up to 4.2kilobases can be stably inserted, deleted or re-arranged at any target gene loci in somatic cell types.

A panel of > 150 X-MAN (mutant & normal) cell-lines are available that model many of common genotypes observed in human cancer, plus provide their perfectly matched normal genetic backgrounds as a reference.

X-MAN cell lines separate the cancer-gene spectrum to aid the discovery of specifically targeted drugs that can be used singularly, or in combination.

Targeting single defects using the X-MAN Discovery 1 panel of cell lines is the first step into understanding how different patient populations respond to a drug; but it is becoming critical to check if other (secondary) mutations impart resistance. This is a key feature of the X-MAN Discovery 2 panel of cell lines (or double Knock-ins). X-MAN Researcher lines are targeted to secondary, epigenetically regulated or modifier genes that are differentially expressed in cancer vs. normal cells.

Horizon also provide a custom cell-line engineering service where your gene of interest can by knocked-in or out of your cell-line of interest. Furthermore Horizon have pioneered and patented novel screening methods using panels of X-MAN cell-lines that enable patient response, stratification resistance profiles to be determined in primary or secondary testing regimes.

Finally, the X-MAN Express range of gDNA and protein cell-lysates enable validation of mutation-based companion diagnostic tests as well as the study of fundamental proteomics research applications.

Academic, Biotech and Pharma customers are already discovering the power of X-MAN cell-lines in a range of drug discovery, drug development and general research applications.

Learn more about the joint GeneWorks and Horizon Discovery offering via our web-site.

Alternatively, please contact Nik Psevdos, National Manager for further information on: nikp@geneworks.com.au

• Display agency product list