Mirus Bio Company Profile

Mirus Bio Corporation is a biopharmaceutical company focused on discovering, developing and commercializing innovative nucleic acid based technologies and products. The company currently markets a range of innovative transfection and labeling reagents worldwide.

Research Reagents and Services

Mirus is a recognized leader in developing innovative nucleic acid research reagents, distinguished by its many accomplishments:

• First to develop an siRNA transfection reagent (2001)
• Pioneered development of high efficiency/low toxicity transfection formulations
• First to market a single step nucleic acid labeling technology
• Unique technology to label native, biologically relevant RNA

Mirus’ TransIT® reagents are unique lipid and polymer formulations that achieve superior delivery efficiency of pDNA and siRNA with minimal cytotoxic effects. They have been optimized for in vitro delivery in a variety of mammalian cells as well as for in vivo delivery in small animals.

The company’s Label IT® kits employ proprietary chemistry to covalently attach labeling molecules to DNA and RNA. This simple one-step process is faster and more robust than traditional multi-step enzymatic labeling, and can be used for intracellular tracking, chromosome analysis, and microarray labeling.

Achieving RNA interference in vivo is a major industry challenge. In this regard, Mirus has developed a breakthrough technology that uses the bloodstream to efficiently deliver siRNAs into specific tissues in adult animals. Using its patented hydrodynamic injection technology, the Company can routinely achieve 60% gene knockdown in the liver cells of research animals. This level of knockdown is unprecedented using a non-viral delivery technology and is faster, cheaper and more versatile than the previous industry standard, knockout mice. Thus, it represents an exciting new tool for metabolic pathway analysis and target identification and validation.

GeneWorks Pty Ltd is proud to announce the distribution of Mirus Bio products for Australia.

To find out more, please contact customerservice@geneworks.com.au

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