Exiqon is a leading provider of high-value gene expression analysis products for the life sciences, research and drug discovery industries. Exiqon's rapidly growing product offerings integrate innovative chemistries with web-based software tools to help scientists achieve rapid and reliable results.
About microRNAs and LNA™
microRNAs (miRNAs) are a novel class of regulatory RNA molecules with surprisingly widespread effects on gene regulation. Although recently identified as a class of molecules, initial studies indicate that miRNAs may regulate as much as 1/3 of all genes in genome, thus comprising an up till now hidden level of regulation. Interestingly, miRNAs have already been found to play important roles in several type of cancers and in processes involved in cellular differentiation. In the cell, miRNAs are found in form of single-stranded RNA molecules, which are typically 20-25 nucleotides long in their active form.
LNAs are a class of nucleotide analogues that bind very strongly to RNA and DNA targets. By including LNAs in detection probes, it is possible to design very specific high-affinity detection assays for small RNA targets like miRNAs, which otherwise is not possible using standard DNA-based detection probes.
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